Winter Term 2020-21 / Neural Behav Sci



Course title

Physiological & Physical Basis of Functional Brain Imaging

Bartels, Braun
Course content / topics

This lecture series provides an in-depth introduction to the most commonly used non-invasive functional neuroimaging tools used in human and non-human neuroscience, with particular emphasis on functional magnetic resonance imaging (fMRI, including brief reference to PET and NIRS imaging) and electro- and magneto-encephalography (EEG and MEG). In particular, it covers three key areas: (A): Physical principles underlying the imaging techniques. This includes physics of nuclear spins, magnetic resonance, MR-spectroscopy, techniques for 3D-image encoding, basics of MR-sequences, electric and magnetic field properties, sensor technology. (B): Physiology leading to the signals. This includes mechanisms of neurovascular coupling, energy consumption and metabolism by various neural processes, organization of cerebral vascularization, regulation of blood flow, dynamics of oxygen consumption; spatial organization of neurons, axons, synaptic transmission and dendritic geometry, generation of electro-magnetic fields. (C): Signal processing and analysis. Various analytical methods will be explained and discussed, including artifact removal techniques, normalization techniques, time-series analysis, uni- and multi-variate analyses, connectivity analyses, statistical correction techniques, and interpretation of results obtained by the different methods. Throughout the course, points are illustrated using original research literature to give the students insight into ongoing research or to classics in the field.

After attendance of this lecture, students will have the theoretical background to understand and critically reflect fMRI, EEG and MEG experiments, they know how to conduct such experiments, know the necessary analysis steps, and know how to interpret results.

Course Topics & Schedule

Day, time & location

Mon, 10 am-12, GTC Lecture Hall