Our research group develops in vitro models based on human induced pluripotent stem cells (human
iPSCs) to investigate developmental and disease mechanisms. We are developing a novel hypothalamic organoid platform to reveal the hypothalamic–pancreatic axis and to understand how the brain regulates metabolism.
For more information, please visit our webpage: www.indb.uni-tuebingen.de
Your tasks
The primary objective of this project is to develop an in vitro human hypothalamic organoid model
and implement it for investigating the hypothalamus-to-pancreas crosstalk under physiological and
disease conditions. Throughout the project, the candidate will gain expertise in:
- human iPSC culture and 3D organoid differentiation
- multi-organoid culture, co-culture models, and assembloids
- advanced staining and imaging techniques
- high-resolution imaging and quantitative analysis
- RNA-based analysis methods
Your profile
- Master’s degree in life sciences, molecular biology, or a related field
- Hands-on experience in mammalian cell culture, particularly with stem cells (experience with hiPSCs will be a great advantage), and proficiency in molecular biology techniques such as qPCR and immunocytochemistry are highly desirable
- Excellent proficiency in English is essential
- Programming skills (e.g. R, Python) and familiarity with scientific software (e.g. ImageJ, Prism) are a plus
Contact & application
If you have any questions or wish to apply, please contact:
Dr. Natalia Pashkovskaia
natalia.pashkovskaia@uni-tuebingen.de
We are looking forward to your application.
Download the information here: